منابع مشابه
Monocyte/macrophage regulation of vascular calcification in vitro.
BACKGROUND Calcification is a common complication of atherosclerosis and other chronic inflammatory processes that involves infiltration of monocytes and accumulation of macrophages. METHODS AND RESULTS To determine whether these cells modulate vascular calcification in vitro, calcifying vascular cells (CVCs), a subpopulation of osteoblast-like cells derived from the artery wall, were cocultu...
متن کاملOsteogenic regulation of vascular calcification: an early perspective.
Cardiovascular calcification is a common consequence of aging, diabetes, hypercholesterolemia, mechanically abnormal valve function, and chronic renal insufficiency. Although vascular calcification may appear to be a uniform response to vascular insult, it is a heterogenous disorder, with overlapping yet distinct mechanisms of initiation and progression. A minimum of four histoanatomic variants...
متن کاملPhosphate regulation of vascular smooth muscle cell calcification.
Vascular calcification is a common finding in atherosclerosis and a serious problem in diabetic and uremic patients. Because of the correlation of hyperphosphatemia and vascular calcification, the ability of extracellular inorganic phosphate levels to regulate human aortic smooth muscle cell (HSMC) culture mineralization in vitro was examined. HSMCs cultured in media containing normal physiolog...
متن کاملRegulation of Vascular Calcification by Osteoclast Regulatory Factors RANKL and OPG Regulation of Vascular Calcification: Roles of Phosphate and Osteopontin Angiogenesis and Pericytes in the Initiation of Ectopic Calcification Bone Morphogenetic Proteins in Vascular Calcification
Vascular calcification is a common problem among the elderly and those with chronic kidney disease (CKD) and diabetes. The process of tunica media vascular calcification in CKD appears to involve a phenotypic change in the vascular smooth muscle cell (VSMC) resulting in cell-mediated mineralization of the extracellular matrix. The bone morphogenetic proteins (BMPs) are important regulators in o...
متن کاملRegulation of Vascular Calcification by Osteoclast Regulatory Factors RANKL and OPG Regulation of Vascular Calcification: Roles of Phosphate and Osteopontin Angiogenesis and Pericytes in Initiation of Ectopic Calcification Role of Bone Morphogenetic Proteins in Vascular Calcification
Vascular calcification is prevalent in aging as well as a number of pathological conditions, and it is now recognized as a strong predictor of cardiovascular events in the general population as well as diabetic and end-stage renal disease patients. Vascular calcification is a highly regulated process involving inductive and inhibitory mechanisms. This article focuses on two molecules, phosphate...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2005
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000161997.24797.c0